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KMID : 0357119970190010083
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Korean Journal of Immunology
1997 Volume.19 No. 1 p.83 ~ p.90
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The Basic Studies on the application of Galetim-3 as a Target Protein for Delivering Anticancer Agents
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Abstract
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Gastric cancer cells express large amounts of galectin-3 on the cell surface. This fact may provide the possibility to use galection-3 protein as a surface target for delivering cytotoxic anticancer agents. To investigate the possibility of
application
of galectin-3 protein as a target protein in delivering cytotoxic anticancer agents, we synthesized doxorubicin immunoconjugate by using maleimidocaproic acid and conjugated doxorubicin immunoconjugate to anti-galection-3 mAb. The anticancer
effect
of
immunotoxin was assayed on NIH3T3, AGS and KATOIII cell lines. The anticancer effect of immunotoxin on AGS cell line is highest and that of KATO III is higher than that of NIH3T3. This results relate to that of flow cytometry analysis previously
shown
and indicate that galectin-3 protein can be used as a target protein on the surface of gastric cancer cell for delivering cytotoxic anticancer agents.
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